The Journal of the American Academy of Child and Adolescent Psychiatry recently published a study ( Tao R et al, 2009 Jan; 48: 71-8 ) that attempts to identify early predictors of response to treatment in depressed children being treated with Fluoxetine. This was a twelve (12) week open label study of 168 depressed youth ( ages 7-18 years). One significant predictor of remission at twelve weeks was a positive first degree family member with a history of depression. Also, a 50% or greater reduction of symptoms at four (4) weeks was the best predictor of remission at twelve weeks ( PPV=88.6%).
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